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July 15, 2008

Could lead to development of synthetic compounds

A boron-nitrogen compound is structurally similar to benzene, a new study reports. These isostructural molecules may act as a substitute for benzene in the development of new medical therapies, according to researchers.

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Test could determine individual response

A common gene mutation affects the body's response to methotrexate, a new study suggests. Researchers at McGill University in Montreal had previously cloned the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene and identified the variant that interferes in folate metabolism in human populations. Now they have shown that alterations in this gene affect the impact of methotrexate.

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Could deliver drugs with no ill effects

Gold nanoparticles coated with alternating bands of materials were able to penetrate cell walls without damaging them, a new study reports. Conversely, similar particles without the "stripes" were entrapped in endosomes when they entered the cells. These findings may enable the delivery of biomolecules into cells without the normally resulting cytotoxicity, the researchers suggested. Attached to the nanoparticles, drugs or other substances could be shepherded into the cytosolic fluid in the cells, where they could exert a desired effect. "We have found a design rule to produce ideal drug delivery vectors that would be able to penetrate cell membranes without damaging them," says senior author Francesco Stellacci, PhD, an associate professor at the Massachusetts Institute of Technology.

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