Back when I was a kid in the 1970s, there were pretty much two ways for oral drugs to be delivered, standard tablets and capsules, and capsules were still fairly novel. I remember an old TV commercial that showed a capsule splitting apart and hundreds of tiny round particles spilling forth.
As peptide-based therapies become increasingly viable drug discovery and development targets, the industry is paying more attention to the quality concerns that underlie peptide-manufacturing processes. Peptide synthesis for pharmaceutical manufacturing can be tedious and time-consuming, given the complexity of the product and the lengthy, intricate synthesis process. Regulatory compliance, quality control, and assurance efforts are critical for the successful development and manufacture of peptides as active pharmaceutical ingredients.
Select abstracts from recent issues of Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, which is published by John Wiley & Sons, which also publishes Pharmaceutical Formulation & Quality.
Opinion: A Global View of Regulations Affecting Nanomaterials
Review: Bioresponsive Polymers for the Delivery of Therapeutic Nucleic Acids
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Microbubbles may be able to carry drugs to a tumor and then burst when exposed to ultrasound, researchers in the United Kingdom proposed. A team at the University of Leeds will investigate the potential
By harnessing hydrodynamic effects, researchers at Virginia Polytechnic Institute and State University (Virginia Tech) have found a way to improve DNA transfection into cells.
Could deliver biochemical agents onto or into a single cell
Gold nanowires guided by electrical fields could deliver biologically active chemicals to a single specified cell or a location within a cell, according to researchers at Johns Hopkins University. The technology could allow precise targeting of a therapeutic agent to cancer cells while leaving surrounding cells untouched, the lead researcher suggested.
